Tips & Notes
Timing
Once weekly subcutaneous injection, same day each week. No strict time of day requirement but consistency matters — pairing it with the same weekly routine as retatrutide or semaglutide if stacking makes adherence easier.
Cycling
Continuous, same rationale as retatrutide — designed as chronic therapy with no defined off-cycle. Discontinuation results in appetite rebound, so stopping should be intentional.
Stacking
Mechanistically complementary to GLP-1 agonists — amylin and GLP-1 hit different hypothalamic pathways, which is exactly why CagriSema outperforms either alone. Stacking with retatrutide is theoretically aggressive but potentially redundant since retatrutide already hits glucagon. Worth flagging on the BeWell catalogue as a GLP-1 adjunct rather than a standalone.
Storage
Lyophilized: fridge for regular use, freezer for long-term. Reconstituted: fridge only, use within 4 weeks, protect from light.
